Prognostic indicators in a range of astrocytic tumours: an immunohistochemical study with Ki-67 and p53 antibodies.

摘要: The treatment and prognosis of patients with cerebral astrocytic tumours are currently guided by histopathological classification. This study evaluates immunohistochemistry using Ki-67, an antibody to a nuclear protein expressed in proliferating cells, DO-7, the product tumour suppressor gene p53, as prognostic indicators for these tumours. Immunohistochemistry Ki-67 has been correlated behaviour many different tumours, but its value indicator is diminished conflicting results previous studies. antibodies p53 used melanomas some carcinomas, relation between accumulation this not clarified. We have tested hypothesis that survival immunolabelling indices (LIs) patterns large cohort (n = 123) whom clinical were well documented. Astrocytic divided into three histological types: fibrillary astrocytoma 24), anaplastic 31), glioblastoma 68). Histological type patient age independent predictors survival. Median LIs differed significantly (P 60%). indicate that, whereas predicts conventional appraisal remains best guide prognosis, no assessment