Angiogenesis: An indicator of metastasis in non-small cell lung cancer invading the thoracic inlet

摘要: Abstract We have attempted to identify a biologic rationale for the local aggressiveness and late treatment failure of rejected non-small cell lung cancer involving thoracic inlet. Tumor specimens from 28 patients who underwent new transcervical approach were analyzed expression tumor proliferative activity, suppressor-gene p53, intranimoral peritumoral blood vessel invasion by cells, presence degree angiogenesis (induction capillaries venules), other variables. Eighty-nine percent neoplasms moderately or poorly differentiated, 89% expressed either an intermediate high proliferate 39% showed p53 aberrations, 71% exhibited induction angiogenesis, had tumors that positive invasion. With median follow-up time 3.5 years (range, 8 145+ months), overall projected 5-year survival was 29% disease-free interval 23 months. Results univariate multivariate analysis identified (density less than 1 versus more number neovessels 6 6) as only independent significant predictors interval. Patients whose density greater faced significantly ( p = 0.0001) higher relative risk suffering systemic recurrence their primary did low-risk counterparts. demonstrate correlates with (metastasis), this is acquired at critical vessels.