Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia.

摘要: Background/Aim: A large number of diseases are ascribed to Helicobacter pylori (H. pylori), particularly chronic active gastritis, peptic ulcer disease and gastric cancer. Successful treatment H. infection with antimicrobial agents can lead regression pylori–associated disorders. Antibiotic resistance against is increasing, it necessary fi nd new effective agents. Nigella sativa seed (NS), a commonly used herb, possesses in vitro anti-helicobacter activity. The present study was undertaken evaluate the effi cacy NS eradication non-ulcer dyspeptic patients. Materials Methods: conducted on 88 adult patients attending King Fahd Hospital University, Al-Khobar, Saudi Arabia, from 2007 2008, symptoms found positive for by histopathology urease test. Patients were randomly assigned four groups, receiving i) triple therapy (TT) comprising clarithromycin, amoxicillin, omeprazole [n= 23], ii) 1 g + 40 mg (OM) 21], iii) 2 OM 21] or iv) 3 23]. Negative stool antigen test weeks after end considered as eradication. Results: 82.6, 47.6, 66.7 47.8% TT, NS, respectively. Eradication rates TT statistically not different each other, whereas other doses signifi cantly less than that (P < 0.05). Dyspepsia improved all groups similar extent. Conclusions: N. seeds possess clinically useful anti-H. activity, comparable therapy. Further clinical studies combining antibiotics suggested.