Apoptosis induced by NS1 gene of Canine Parvovirus-2 is caspase dependent and p53 independent
作者： Lovleen Saxena , G. Ravi Kumar , Shikha Saxena , Uttara Chaturvedi , Aditya Prasad Sahoo
DOI: 10.1016/J.VIRUSRES.2013.01.020
关键词:
摘要: Apoptosis is programmed cell death that normally occurs during development and aging in multicellular animals. also as a defense mechanism against disease or harmful external agents. It can be initiated by variety of stimuli including viruses viral proteins. Canine parvovirus type 2 (CPV-2) causes acute dogs has been found to induce cycle arrest DNA damage leading cellular lysis. Though non structural protein 1 (NS1) many parvoviruses apoptotic, no report on the apoptotic potential NS1 CPV-2 (CPV-2.NS1) exists. In this study, we evaluated CPV-2.NS1 HeLa cells. apoptosis which was evident through characteristic fragmentation, increase hypodiploid count, phosphatidyl serine translocation activation caspase-3. Increase caspase-3 activity change p53 with time expressing cells showed induction caspase dependent independent.
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