Epidermal growth factor receptor expression in primary laryngeal cancer: An independent prognostic factor of neck node relapse
作者： Giovanni Almadori , Gabriella Cadoni , Jacopo Galli , Gabriella Ferrandina , Giovanni Scambia
DOI: 10.1002/(SICI)1097-0215(19990420)84:2<188::AID-IJC16>3.0.CO;2-1
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摘要: Specimens of laryngeal squamous cell carcinoma (LSCC) were examined for epidermal growth factor receptor (EGFR) content using a radioreceptor method; 140 untreated consecutive patients with primary LSCC undergoing initial surgical resection followed up median 49 months (range 2–84 months) after surgery. Cox univariate regression analysis EGFR as continuous variable showed that levels directly associated the risk lymph node metastasis. A significant relationship between status and cervical metastasis was observed. The cutoff value 20 fmol/mg protein best prognostic discriminator. 5-year metastasis-free survival (MFS) 66% EGFR− tumors compared 15% EGFR+ tumors. By multivariate analysis, appeared to be independent MFS. Our results suggest assessment at time diagnosis may identify subset highly susceptible neck metastases thus defining therapy accordingly. Int. J. Cancer (Pred. Oncol.) 84:188–191, 1999. © 1999 Wiley-Liss, Inc.
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