Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost.

摘要: Purpose: Standard radiation for early breast cancer requires daily treatment 6 to 7 weeks. This is an inconvenience many women, and some a barrier conservation. We present the acute toxicity of 4-week course hypofractionated radiation. Methods Materials: A total 75 patients completed on Phase II trial approved by hospital institutional review board. Eligibility criteria were broad include any patient normally eligible standard radiation: age ≥18 years, invasive or in situ cancer, American Joint Committee Cancer Stage 0 II, breast-conserving surgery, systemic therapy not given concurrently. The median was 52 years (range, 31–81 years). Of patients, 15% had ductal carcinoma , 67% T1, 19% T2; 71% N0, 17% N1, 12% NX. Chemotherapy before 44%. Using photon intensity-modulated incorporated electron beam boost, whole received 45 Gy lumpectomy bed 56 20 treatments over 4 Results: maximum skin end Grade 9 (12%), 1 49 (65%) 2 17 (23%). There no 3 higher toxicity. After radiation, all resolved Hematologic most except neutropenia anemia 11 patients. significant differences baseline vs. 6-week posttreatment patient-reported physician-reported cosmetic scores. Conclusions: postoperative using feasible associated with acceptable quality life. Long-term follow-up data are needed. schedule may represent alternative both longer 7-week whole-breast more radically shortened 1-week, partial-breast schedules.