Method to detect prostate cancer in a sample
作者： Camille Chypre , Genevieve Garon , Yves Fradet , Lyson Piche
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摘要: The present invention provides methods to detect prostate cancer by detecting the RNA encoded PCA3. disclosure a method for determining predisposition, or presence of comprising: (a) contacting sample with at least one oligonucleotide that hybridizes PCA3 polynucleotide; (b) an amount and second prostate-specific polynucleotides; (c) comparing polynucleotide predetermined cut off value, absence cancer. Diagnostic kits are provided risk developing same container means containing probe primer specific nucleic acid; reagents acid.
lens.org参考文章(216)
D. Sainsbury, P. Singleton, Dictionary of microbiology and molecular biology. 2nd ed John Wiley and Sons Inc.,New York, NY. ,(1988)
James Iwakiri, Kay Grandbois, Nancy Wehner, Howard C.B. Graves, Thomas Stamey, An Analysis of Urinary Prostate Specific Antigen Before and After Radical Prostatectomy: Evidence for Secretion of Prostate Specific Antigen by the Periurethral Glands Journal of Urology. ,vol. 149, pp. 783- 786 ,(1993) , 10.1016/S0022-5347(17)36207-9
Xandra O. Breakefield, Ole Isacson, William S. Rosenberg, Method of gene delivery to post-mitotic cells ,(1992)
W. Scott Grayburn, Thomas L. Sims, Anchored oligo(dT) primers for automated dye terminator DNA sequencing. BioTechniques. ,vol. 25, pp. 340- 346 ,(1998) , 10.2144/98253BM01
Stephen C. Macevicz, Nucleic acid sequence determination by multiple mixed oligonucleotide probes ,(1988)
Michael K. Brawer, Michael P. Chetner, Jeanette Beatie, David M. Buchner, Robert L. Vessella, Paul H. Lange, Screening for Prostatic Carcinoma with Prostate Specific Antigen The Journal of Urology. ,vol. 147, pp. 841- 845 ,(1992) , 10.1016/S0022-5347(17)37401-3
Kamoi K, Babaian Rj, Advances in the application of prostate-specific antigen in the detection of early-stage prostate cancer. Seminars in Oncology. ,vol. 26, pp. 140- 149 ,(1999)
Arnd Michaelis, Melvin M. Green, Rigomar Rieger, Glossary of Genetics: Classical and Molecular ,(2011)
Paul S. Miller, Paul O.P. Ts'o, Chapter 30. Oligonucleotide Inhibitors of Gene Expression in Living Cells: New Opportunities in Drug Design Annual Reports in Medicinal Chemistry. ,vol. 23, pp. 295- 304 ,(1988) , 10.1016/S0065-7743(08)60858-1
R. Lathe, Synthetic oligonucleotide probes deduced from amino acid sequence data. Theoretical and practical considerations. Journal of Molecular Biology. ,vol. 183, pp. 1- 12 ,(1985) , 10.1016/0022-2836(85)90276-1