The effects of paroxetine given repeatedly on the 5-HT receptor subpopulations in the rat brain
作者： J. Maj , M. Bijak , M. Dziedzicka-Wasylewska , R. Rogoż , Z. Rogóż
DOI: 10.1007/BF02805977
关键词:
摘要: Effects of paroxetine (10 mg/kg PO, twice daily, 14 days) on 5-HT receptor subpopulations in the brain were evaluated pharmacologically, electrophysiologically and biochemically male Wistar rats. Imipramine was used for comparison. Repeated antagonized 8-OH-DPAT-induced behavioural syndrome (a-HT1A effect); imipramine showed similar, yet weaker, activity. The 5-HT- or inhibition population spikes hippocampal slices increased by both those repeated antidepressants. (or acute) decreased density affinity 5-HT1A receptors ([3H]-8-OH-DPAT as ligand) hippocampus, while induced opposite effects.m-Chlorophenyl piperazine (m-CPP)-evoked exploratory hypoactivity, a 5-HT2C effect, reduced paroxetine, but not imipramine. Either antidepressants given repeatedly TFMPP-induced hyperthermia (another putative effect). 5-HTP-induced head twitches (a 5-HT2A effect) inhibited antidepressant ([3H-ketanserin cortex, did change their affinity. present results indicate that induces secondary changes 5-HT2 receptors, which lead to reduction neurotransmission (reduced responsiveness postsynaptic receptors). consequences found here still await clarification.
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