Proteomic analysis reveals ATP-dependent steps and chaperones involvement in luteolin-induced lung cancer CH27 cell apoptosis.
作者： Hong-Zin Lee , Wen-Hui Yang , Bo-Ying Bao , Pei-Ling Lo
DOI: 10.1016/J.EJPHAR.2010.05.053
关键词:
摘要: The present study applied 2D electrophoresis to analyze the proteins involved in luteolin (50 microM)-induced CH27 cell apoptosis. We found 7 be markedly changed. According data of analysis these protein spots, we hypothesized that ATP synthetic pathway and heat shock were luteolin-induced In this study, induced a significant change intracellular levels mitochondrial activity cells. Further experiments demonstrated pretreatment with forskolin blocked death. P38 27 may important participants changes organization actin microfilaments study. addition, endoplasmic reticulum stress is also Our findings suggested function mitochondria integral factor
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