Ocimum Sanctum L (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer

摘要: Ocimum sanctum L. or tenuiflorum L, commonly known as the Holy Basil in English Tulsi various Indian languages, is a important medicinal plant traditional and folk systems of medicine Southeast Asia. Scientific studies have shown it to possess antiinflammatory, analgesic, antipyretic, antidiabetic, hepatoprotective, hypolipidemic, antistress, immunomodulatory activities. Preclinical also that some its phytochemicals eugenol, rosmarinic acid, apigenin, myretenal, luteolin, β-sitosterol, carnosic acid prevented chemical-induced skin, liver, oral, lung cancers mediate these effects by increasing antioxidant activity, altering gene expressions, inducing apoptosis, inhibiting angiogenesis metastasis. The aqueous extract flavanoids, orintin, vicenin are protect mice against γ-radiation-induced sickness mortality selectively normal tissues tumoricidal radiation. other like prevent radiation-induced DNA damage. This review summarizes results related chemopreventive radioprotective properties emphasizes aspects warrant future research establish activity utility cancer prevention treatment.