LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma
作者： Fengqin Hao , Yanan Mou , Laixia Zhang , Shuna Wang , Yang Yang
DOI: 10.1042/BSR20180384
关键词:
摘要: The actin filament-associated protein 1 antisense RNA (AFAP1-AS1) has been found to serve as an oncogenic long noncoding (lncRNA) in most types of human cancer. role AFAP1-AS1 retinoblastoma remains unknown. purpose the present study is explore clinical significance and biological function retinoblastoma. Levels expression were measured tissues cell lines. Loss-of-function was performed observe effects on proliferation, cycle, migration, invasion. In our results, elevated lines, associated with tumor size, choroidal invasion, optic nerve Moreover, high independent unfavorable prognostic factor patients. experiment vitro suggested down-regulation inhibited migration blocked cycle. conclusion, functions lncRNA
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