Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population.

摘要: Growth factors are polypeptides that critical for the initiation, progression, and metastasis of cancer. Most tumor cells capable synthesizing particular growth leading to constitutive pathway activation in these through autocrine signaling. Epidermal factor (EGF) is a potent mitogenic peptide exerts direct effects on proliferation differentiation carcinogenesis. By contrast, vascular endothelial (VEGF) vital invasion neoplasms formation new blood vessels from mature cells. In this study, we investigated association between functional polymorphisms both EGF VEGF genes colorectal cancer (CRC) susceptibility. A total 130 CRC patients 212 healthy controls were recruited case-control study. Genotyping genetic variants was conducted via real-time polymerase chain reaction (PCR) amplification with allele-specific TaqMan probes. None genotypes +61 A>G +936 C>T significantly associated susceptibility among Malaysian subjects evaluated (P > 0.05). The observed frequency distributions polymorphism showed ethnic heterogeneity, which not case genotypes. conclusion, no positive correlation risk found population. Studies scarce, results reported thus far differ one population another. Hence, more replication studies warranted before any firm conclusions can be made.