Molecular-targeted therapies in the treatment of squamous cell carcinomas of the head and neck

作者: Christophe Le Tourneau , Lillian L Siu

DOI: 10.1097/CCO.0B013E3282F9B575

关键词:

摘要: Purpose of reviewThe present study reviews recent developments molecular-targeted therapies in the treatment recurrent and/or metastatic head and neck squamous cell carcinoma. It also highlights ongoing research regarding predictive markers sensitivity or resistance to anti-epidermal growth

参考文章(44)
Pornchai O-charoenrat, Peter Rhys-Evans, Helmout Modjtahedi, Suzanne A. Eccles, Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells. Clinical & Experimental Metastasis. ,vol. 18, pp. 155- 161 ,(2000) , 10.1023/A:1006764100867
R. Hitt, A. Irigoyen, J. Nuñez, J. Grau, J. Garcia Saenz, M. Pastor, C. Jara, C. Garcia Giron, M. Hidalgo, J. Cruz Hernandez, Phase II study of combination cetuximab and weekly paclitaxel in patients with metastatic/recurrent squamous cell carcinoma of head and neck (SCCHN): Spanish Head and Neck Cancer Group (TTCC) Journal of Clinical Oncology. ,vol. 25, pp. 6012- 6012 ,(2007) , 10.1200/JCO.2007.25.18_SUPPL.6012
Christine Elser, Lillian L. Siu, Eric Winquist, Mark Agulnik, Gregory R. Pond, Soo F. Chin, Peggy Francis, Robin Cheiken, James Elting, Angela McNabola, Dean Wilkie, Oana Petrenciuc, Eric X. Chen, Phase II Trial of Sorafenib in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Nasopharyngeal Carcinoma Journal of Clinical Oncology. ,vol. 25, pp. 3766- 3773 ,(2007) , 10.1200/JCO.2006.10.2871
Mario E. Lacouture, Mechanisms of cutaneous toxicities to EGFR inhibitors. Nature Reviews Cancer. ,vol. 6, pp. 803- 812 ,(2006) , 10.1038/NRC1970
Michalis V. Karamouzis, Jennifer R. Grandis, Athanassios Argiris, Therapies Directed Against Epidermal Growth Factor Receptor in Aerodigestive Carcinomas JAMA. ,vol. 298, pp. 70- 82 ,(2007) , 10.1001/JAMA.298.1.70
A M Kirby, R P A'Hern, C D'Ambrosio, M Tanay, K N Syrigos, S J Rogers, C Box, S A Eccles, C M Nutting, K J Harrington, Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer. British Journal of Cancer. ,vol. 94, pp. 631- 636 ,(2006) , 10.1038/SJ.BJC.6602999
Phillipe Lothaire, Evandro de Azambuja, Didier Dequanter, Yassine Lalami, Christos Sotiriou, Guy Andry, Gilberto Castro, Ahmad Awada, Molecular markers of head and neck squamous cell carcinoma: promising signs in need of prospective evaluation. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 28, pp. 256- 269 ,(2006) , 10.1002/HED.20326
A Jimeno, P Kulesza, J Wheelhouse, A Chan, X Zhang, E Kincaid, R Chen, D P Clark, A Forastiere, M Hidalgo, Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy. British Journal of Cancer. ,vol. 96, pp. 952- 959 ,(2007) , 10.1038/SJ.BJC.6603656
Nasredine Aissat, Christophe Le Tourneau, Aïda Ghoul, Maria Serova, Ivan Bieche, François Lokiec, Eric Raymond, Sandrine Faivre, Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines Cancer Chemotherapy and Pharmacology. ,vol. 62, pp. 305- 313 ,(2008) , 10.1007/S00280-007-0609-2
Hwan Jung Yun, Jan Bogaerts, Ahmad Awada, Denis Lacombe, Clinical trial design limitations in head and neck squamous cell carcinomas. Current Opinion in Oncology. ,vol. 19, pp. 210- 215 ,(2007) , 10.1097/CCO.0B013E3280D2B8D7