Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens
作者： Flavius Martin , Alyce M Oliver , John F Kearney
DOI: 10.1016/S1074-7613(01)00129-7
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摘要: The rate of pathogen elimination determines the extent and consequences an infection. In this context, spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue their preactivated state topographical location, join B1 to generate massive wave IgM producing plasmablasts initial 3 days primary response particulate bacterial antigens. Because intensity rapidity response, combined types antibodies produced, splenic MZ endowed "natural memory" provide bridge between very early innate later appearing adaptive immune response.
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