Outcome of Primary Tumor in Patients With Synchronous Stage IV Colorectal Cancer Receiving Combination Chemotherapy Without Surgery As Initial Treatment

作者: George A. Poultsides , Elliot L. Servais , Leonard B. Saltz , Sujata Patil , Nancy E. Kemeny

DOI: 10.1200/JCO.2008.20.9817

关键词:

摘要: Purpose The purpose of this study was to describe the frequency interventions necessary palliate intact primary tumor in patients who present with synchronous, stage IV colorectal cancer (CRC) and receive up-front modern combination chemotherapy without prophylactic surgery. Patients Methods By using a prospective institutional database, we identified 233 consecutive from 2000 through 2006 synchronous metastatic CRC an unresected received oxaliplatin- or irinotecan-based, triple-drug (infusional fluorouracil, leucovorin, oxaliplatin; bolus irinotecan; irinotecan) bevacizumab as their initial treatment. incidence subsequent use surgery, radiotherapy, and/or endoluminal stenting manage complications recorded. Results Of patients, 217 (93%) never required surgical palliation tumor. Sixteen (7%) requir...

参考文章(21)
J. Mella, A. Biffin, A. G. Radcliffe, J. D. Stamataki, R. J. C. Steele, Population‐based audit of colorectal cancer management in two UK health regions British Journal of Surgery. ,vol. 84, pp. 1731- 1736 ,(1997) , 10.1046/J.1365-2168.1997.02869.X
Seth A. Rosen, Initial Presentation With Stage IV Colorectal Cancer Archives of Surgery. ,vol. 135, pp. 530- 534 ,(2000) , 10.1001/ARCHSURG.135.5.530
Charles R. Scoggins, Ingrid M. Meszoely, Charles D. Blanke, R. Daniel Beauchamp, Steven D. Leach, Nonoperative management of primary colorectal cancer in patients with stage IV disease. Annals of Surgical Oncology. ,vol. 6, pp. 651- 657 ,(1999) , 10.1007/S10434-999-0651-X
Pierre Michel, Isabelle Roque, Frédéric Di Fiore, Sophie Langlois, Michel Scotte, Paul Tenière, Bernard Paillot, Colorectal cancer with non-resectable synchronous metastases: should the primary tumor be resected? Gastroenterologie Clinique Et Biologique. ,vol. 28, pp. 434- 437 ,(2004) , 10.1016/S0399-8320(04)94952-4
A. I. Sarela, J. A. Guthrie, M. T. Seymour, E. Ride, P. J. Guillou, D. S. O'Riordain, Non-operative management of the primary tumour in patients with incurable stage IV colorectal cancer British Journal of Surgery. ,vol. 88, pp. 1352- 1356 ,(2002) , 10.1046/J.0007-1323.2001.01915.X
Fairooz F. Kabbinavar, Julie Hambleton, Robert D. Mass, Herbert I. Hurwitz, Emily Bergsland, Somnath Sarkar, Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer Journal of Clinical Oncology. ,vol. 23, pp. 3706- 3712 ,(2005) , 10.1200/JCO.2005.00.232
Larissa K.F. Temple, Lillian Hsieh, W. Douglas Wong, Leonard Saltz, Deborah Schrag, Use of Surgery Among Elderly Patients With Stage IV Colorectal Cancer Journal of Clinical Oncology. ,vol. 22, pp. 3475- 3484 ,(2004) , 10.1200/JCO.2004.10.218