A quantitative study of blood-brain barrier permeability ultrastructure in a new rat glioma model.

摘要: Cerebral edema, a major complication of tumors in the brain, is result an alteration blood-brain barrier (B-BB). The vascular ultrastructural changes that underlie edema formation have been described variety tumors. Interendothelial junction abnormalities, fenestrations, and large numbers tubulo-vesicular profiles tumor endothelium presumed to represent permeability routes permit escape serum constituents into tumor, from where they flow surrounding brain. Descriptive studies do not provide information on relative frequency these presumptive routes.