Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.
作者： C. David James , Greg Eley , Xiao Yang Wang , Lori Frederick
DOI:
关键词:
摘要: … and diversity of EGFR mutations in glioblastomas and to determine whether gene mutation is … No mutations were identified in the 22 tumors without EGFR amplification. An additional 26 …
aacrjournals.org参考文章(33)
W. K. Alfred Yung, Polly Lee, Mien Chie Hung, Peter A. Steck, Expression of an Altered Epidermal Growth Factor Receptor by Human Glioblastoma Cells Cancer Research. ,vol. 48, pp. 5433- 5439 ,(1988)
S J Decker, C Alexander, T Habib, Epidermal growth factor (EGF)-stimulated tyrosine phosphorylation and EGF receptor degradation in cells expressing EGF receptors truncated at residue 973. Journal of Biological Chemistry. ,vol. 267, pp. 1104- 1108 ,(1992) , 10.1016/S0021-9258(18)48402-5
Cheri S. Lazar, Alan Wells, Gordon N. Gill, Hideo Masui, Michael G. Rosenfeld, Enhanced Tumorigenesis of NR6 Cells Which Express Non-Down-Regulating Epidermal Growth Factor Receptors Cancer Research. ,vol. 51, pp. 6170- 6175 ,(1991)
Ralf F. Pettersson, A. Jonas Ekstrand, C. David James, V. Peter Collins, V. Peter Collins, Barbara Seliger, Webster K. Cavenee, Genes for Epidermal Growth Factor Receptor, Transforming Growth Factor α, and Epidermal Growth Factor and Their Expression in Human Gliomas in Vivo Cancer Research. ,vol. 51, pp. 2164- 2172 ,(1991)
U. Novak, A. W. Burgess, A. H. Kaye, L. T. Malden, Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme. Cancer Research. ,vol. 48, pp. 2711- 2714 ,(1988)
H Yamazaki, Y Fukui, Y Ueyama, N Tamaoki, T Kawamoto, S Taniguchi, M Shibuya, Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors. Molecular and Cellular Biology. ,vol. 8, pp. 1816- 1820 ,(1988) , 10.1128/MCB.8.4.1816
N. Longo, J. J. Olson, M. L. Hamid, A. J. Ekstrand, V. P. Collins, Lu Liu, C. D. James, Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification. Oncogene. ,vol. 9, pp. 2313- 2320 ,(1994)
A. J. Wong, J. M. Ruppert, S. H. Bigner, C. H. Grzeschik, P. A. Humphrey, D. S. Bigner, B. Vogelstein, Structural alterations of the epidermal growth factor receptor gene in human gliomas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 2965- 2969 ,(1992) , 10.1073/PNAS.89.7.2965
William S. Chen, Cheri S. Lazar, Kirk A. Lund, John B. Welsh, Chia-Ping Chang, Gordon M. Walton, Channing J. Der, H.Steven Wiley, Gordon N. Gill, Michael G. Rosenfeld, Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Cell. ,vol. 59, pp. 33- 43 ,(1989) , 10.1016/0092-8674(89)90867-2
Towia A. Libermann, Harris R. Nusbaum, Nissim Razon, Richard Kris, Irit Lax, Hermona Soreq, Nigel Whittle, Michael D. Waterfield, Axel Ullrich, Joseph Schlessinger, Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin Nature. ,vol. 313, pp. 144- 147 ,(1985) , 10.1038/313144A0