Integrins mediate a neuronal survival signal for oligodendrocytes

摘要: Target-dependent survival of newly differentiated cells is an important part neural development. In the case myelin-forming oligodendrocytes, it matches number oligodendrocytes to available axons [1]. addition growth factors, axonal signal regulates this survival: when are transected, die and, conversely, increased by genetic manipulation, oligodendrocyte numbers increase [2] [3]. Newly formed that fail contact undergo apoptosis, and co-culture experiments model axon-glial interactions in vitro reveal a neuronal effect not present neuron-conditioned medium [4] [5], suggesting non-diffusible on surface axons. The nature these signals unknown, as mechanisms which they interact with growth-factor-mediated signals. As integrins can regulate other cell types [6] [7] [8], we determined whether involved effect. We found laminin receptor alpha6beta1 integrin, expressed enhances sensitivity factors. On basis interaction between integrin signalling, propose simple from might numbers.