BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

摘要: Rearrangement of RET proto-oncogene is the major event in etiopathogenesis papillary thyroid carcinoma (PTC). We report a high prevalence BRAF(V599E) mutation sporadic PTC and PTC-derived cell lines. The was detected 23 50 (46%) three four highest reported to date human carcinomas, being only exceeded by melanoma. with RET/PTC rearrangement as well TPC-1 line (the one harboring rearrangement) did not show mutation. any nodular goiters, 51 follicular adenomas 18 carcinomas. A distinct BRAF (codon K600E) adenoma. Activating mutations RAS genes were 15% FA, 33% FTC 7% PTC. coexist alterations tumors. These results suggest that frequent appears be an alternative rather than mutations, which are rare may represent pathway oncogenic MAPK activation PTCs without activation.