Clinical Features and Drug-Resistance Profile of Urinary Tuberculosis in South-Western China: A Cross-sectional Study

摘要: To investigate the epidemiology, clinical features, and drug-resistance profile of urinary tuberculosis (UTB) in south-western China to improve UTB diagnostics.After screening 1036 cases suspected UTB, 193 patients with were enrolled during 2009 2014. Urine samples collected for routine urinalysis, smear, DNA (TB-DNA) detection, drug-resistant analysis, whereas blood erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), renal function evaluation. Clinical features (such as symptoms outcome) imageology results B ultrasonic, computerized tomography, intravenous pyelography, renography) also analyzed profile.The most common presenting irritation (61.1%) lumbago (49.2%). High proportions microscopic hematuria (63.2%) proteinuria (45.6%) observed. The positive TB-DNA was 66.3%. culture 13.1% smear it 9.8%. abnormal outcome rates ultrasonography, nephrogram 76.9%, 70.1%, 29.8%, 37.0%, respectively. total TB (resistant at least 1 drug) 39.7%, which 20.7% multidrug-resistance TB. prevalent mutation sites katG S315T1, rpoB S531L, gyrA D94G.We observed a serious epidemic substantial number new multidrug resistance Molecular diagnostics is crucial definite diagnosis our finding supplement further confirmation polymerase chain reaction usage diagnosis. We recommend real-time identification instead culture, GenoType tests (MTBDRplus MTBDRsl assay) drug assays UTB.