Tracer kinetic evidence for abnormal methyl metabolism in schizophrenia

摘要: The original transmethylation hypothesis of schizophrenia has evolved with time and experiment to the present concept that a defect in methyl-carbon metabolic pathway may be causative this illness. Various researchers have proposed specific steps defective, presented evidence support these possibilities. We tested general by administering methionine labeled 11C or 14C S-methyl carbon patients controls measured expiration 11CO2 14CO2. found rate total CO2 were three times less than controls, no overlap data points two groups. Specific methylcarbon might defective produce results seen here are discussed light other researchers' findings.