Effect of oral glucose administration on ghrelin levels in obese children
作者： L Soriano-Guillen , V Barrios , G Martos , JA Chowen , A Campos-Barros
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摘要: Objective: Coexpression of GH secretagogue receptor and ghrelin in the pancreas suggests that this peptide is involved glucose metabolism. Previous reports adult humans have demonstrated plasma levels decrease after oral administration. However, no data are available children. Therefore, aim study was to analyze response obese children Subjects methods: Twenty-eight ranging from Tanner I V were studied. All subjects given 0.75 g/kg (maximum 75 g) solution overnight fasting. Ghrelin, insulin, IGF-binding-protein-1 determined at 0, 30, 60 120 min tolerance test (OGTT). Results: Basal significantly lower than respective control groups. These decreased during OGTT children, reaching a nadir 28^9% parallel with maximum increase previous insulin levels. Conclusion: The rapid fall concentration load mechanism for appetite food intake.
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