Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

作者: Anthony C Faber , Anna F Farago , Carlotta Costa , Anahita Dastur , Maria Gomez-Caraballo

DOI: 10.1073/PNAS.1411848112

关键词:

摘要: … By matching cell line sensitivity to two independent gene expression data sets, we found a modest, but significant, correlation between BIM expression and sensitivity to ABT-263 (Fig. …

参考文章(45)
Hiromichi Ebi, Carlotta Costa, Jeffrey A. Engelman, Anthony C. Faber, Apoptosis In Targeted Therapy Responses Advances in Pharmacology. ,vol. 65, pp. 519- 542 ,(2012) , 10.1016/B978-0-12-397927-8.00016-6
Alex R. Shoemaker, Michael J. Mitten, Jessica Adickes, Scott Ackler, Marion Refici, Debra Ferguson, Anatol Oleksijew, Jacqueline M. O'Connor, Baole Wang, David J. Frost, Joy Bauch, Kennan Marsh, Steven K. Tahir, Xiufen Yang, Christin Tse, Stephen W. Fesik, Saul H. Rosenberg, Steven W. Elmore, Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models Clinical Cancer Research. ,vol. 14, pp. 3268- 3277 ,(2008) , 10.1158/1078-0432.CCR-07-4622
Kate D. Sutherland, Natalie Proost, Inge Brouns, Dirk Adriaensen, Ji-Ying Song, Anton Berns, Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung Cancer Cell. ,vol. 19, pp. 754- 764 ,(2011) , 10.1016/J.CCR.2011.04.019
Kylie D. Mason, Cassandra J. Vandenberg, Clare L. Scott, Andrew H. Wei, Suzanne Cory, David C. S. Huang, Andrew W. Roberts, In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 17961- 17966 ,(2008) , 10.1073/PNAS.0809957105
Ralph Meuwissen, Sabine C Linn, R.Ilona Linnoila, John Zevenhoven, Wolter J Mooi, Anton Berns, Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model Cancer Cell. ,vol. 4, pp. 181- 189 ,(2003) , 10.1016/S1535-6108(03)00220-4
M. Nguyen, R. C. Marcellus, A. Roulston, M. Watson, L. Serfass, S. R. Murthy Madiraju, D. Goulet, J. Viallet, L. Belec, X. Billot, S. Acoca, E. Purisima, A. Wiegmans, L. Cluse, R. W. Johnstone, P. Beauparlant, G. C. Shore, Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 19512- 19517 ,(2007) , 10.1073/PNAS.0709443104
A. Y. Choo, S.-O. Yoon, S. G. Kim, P. P. Roux, J. Blenis, Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 17414- 17419 ,(2008) , 10.1073/PNAS.0809136105
A. C. Faber, D. Li, Y. Song, M.-C. Liang, B. Y. Yeap, R. T. Bronson, E. Lifshits, Z. Chen, S.-M. Maira, C. Garcia-Echeverria, K.-K. Wong, J. A. Engelman, Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 19503- 19508 ,(2009) , 10.1073/PNAS.0905056106
Ute A. Sartorius, Peter H. Krammer, Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. International Journal of Cancer. ,vol. 97, pp. 584- 592 ,(2002) , 10.1002/IJC.10096
X Lin, S Morgan-Lappe, X Huang, L Li, D M Zakula, L A Vernetti, S W Fesik, Y Shen, 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737 Oncogene. ,vol. 26, pp. 3972- 3979 ,(2007) , 10.1038/SJ.ONC.1210166