Aberrant signaling pathways in glioma.
作者： Mitsutoshi Nakada , Daisuke Kita , Takuya Watanabe , Yutaka Hayashi , Lei Teng
关键词:
摘要: Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this exemplified by prominent proliferation, active invasiveness, rich angiogenesis. This mainly due to highly deregulated signaling pathways tumor. Studies these have greatly increased our understanding biology clinical behavior GBM. An integrated view signal transduction will provide more useful approach designing novel therapies for devastating disease. In review, we summarize current GBM with focus on potential molecular targets anti-signaling therapies.
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Hiroko Ohgaki, Epidemiology of brain tumors. Methods of Molecular Biology. ,vol. 472, pp. 323- 342 ,(2009) , 10.1007/978-1-60327-492-0_14
Masabumi Shibuya, Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor FEBS Journal. ,vol. 276, pp. 4636- 4643 ,(2009) , 10.1111/J.1742-4658.2009.07175.X
Wahrer Dc, Haber Da, Louis Dn, Bell Dw, Ino Y, Mutation analysis of the hCHK2 gene in primary human malignant gliomas Neurogenetics. ,vol. 3, pp. 45- 46 ,(2000) , 10.1007/PL00022979
G Reifenberger, K Ichimura, V P Collins, E E Schmidt, CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Research. ,vol. 54, pp. 6321- 6324 ,(1994)
Wallace McKeehan, Janet M. Bruner, Mitchel S. Berger, Mark Tang, Fumio Yamaguchi, Richard S. Morrison, Fibroblast Growth Factor Receptor Gene Expression and Immunoreactivity Are Elevated in Human Glioblastoma Multiforme Cancer Research. ,vol. 54, pp. 2794- 2799 ,(1994)
G E Palade, W G Roberts, Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Research. ,vol. 57, pp. 765- 772 ,(1997)
K Ichimura, Maria Bondesson Bolin, Helena M Goike, Esther E Schmidt, Ahmad Moshref, V Peter Collins, Deregulation of the p14ARF/MDM2/p53 Pathway Is a Prerequisite for Human Astrocytic Gliomas with G1-S Transition Control Gene Abnormalities Cancer Research. ,vol. 60, pp. 417- 424 ,(2000)
H-J. Su Huang, Webster K. Cavenee, Frank B. Furnari, The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells Cancer Research. ,vol. 58, pp. 5002- 5008 ,(1998)
Andreas von Deimling, Jimmy T. Efird, John W. Henson, David N. Louis, Yasuhiro Ono, Keisuke Ueki, CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated Cancer Research. ,vol. 56, pp. 150- 153 ,(1996)
David Sidransky, Geoffrey I. Shapiro, Christian D. Edwards, Li Mao, Barrett J. Rollins, Gauri Bedi, Adrian Merlo, A Novel p16INK4A Transcript Cancer Research. ,vol. 55, pp. 2995- 2997 ,(1995)