Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.

摘要: Activation of the RAS/RAF/extracellular signal-regulated kinase-mitogen-activated protein kinase/extracellular kinase/mitogen-activated kinase pathway by RAS mutations is commonly found in human cancers. Recently, we reported that mutation BRAF provides an alternative route for activation this signaling and can be melanomas, colorectal cancers, ovarian tumors. Here perform extensive characterization a large series tumors various stages neoplastic transformation. were 11 215 (5.1%) adenocarcinomas, 3 108 (2.8%) sporadic adenomas, 1 63 (1.6%) adenomas from familial adenomatous polyposis (FAP) patients, (33%) hyperplastic polyps. KRAS detected 34% carcinomas, 31% 9% FAP no Eight 16 V599E, previously described hotspot, none these was associated with same lesion. The remaining eight involve other conserved amino acids domain, 62.5% have tumor. Our data suggest are, to some extent, biologically similar cancer because both occur at approximately stage adenoma-carcinoma sequence, are villous morphology, less common cases. By contrast, adenocarcinomas early Dukes' tumor (P = 0.006) such relationship observed mutations. presence neoplasms suggests modulation RAS-RAF-extracellular may multiple components.