Class I antigens of the major histocompatibility complex on cytotrophoblast of the human placental basal plate.

摘要: The lack of class I antigens the major histocompatibility complex (MHC) on syncytiotrophoblast has been proposed as an explanation for survival allogeneic fetus. These antigens, however, have recently detected nonvillous trophoblastic columns early human placenta. By using a combination immunofluorescence techniques to identify trophoblast, we studied transplantation cytotrophoblastic shell present in basal plate normal full-term placentae. With use two different monoclonal antibodies common determinant HLA (clones W6/32 and 61D2), it was shown that this subset trophoblast does express 1 MHC antigens. However, while these cells reacted uniformly with W6/32, only rare reactivity 61D2 found. Reactivity polyclonal antisera beta 2-microglobulin correlated seen W6/32. results are similar those observed amniochorion which term "metatrophoblast" given.