Gene delivery of apoptin-derived peptide using an adeno-associated virus vector inhibits glioma and prolongs animal survival.
作者： Xiuli Zhong , Hengyu Zhao , Songhe Liang , DanYang Zhou , Wenjia Zhang
DOI: 10.1016/J.BBRC.2016.10.059
关键词:
摘要: Glioblastoma (GBM) is the most common malignant brain tumor in adults. We designed an adeno-associated virus (AAV) vector for intracranial delivery of secreted HSP70-targeted peptide APOPTIN derived from Apoptin to GBM tumors. applied this therapy models using human U87MG glioma cells and xenograft mice. In U251MG cells, conditioned medium AAV2-apoptin-derived (ADP)-expressing induced 83% 78% cell death. mice bearing tumors treated with AAV2-ADP, treatment resulted a significant decrease growth longer survival orthotopic invasive These data indicate that ssAAV2-ADP injection left hemisphere effectively prevented ipsilateral but was insufficient prevent distal contralateral hemisphere. However, systemic route effective approach treating widely dispersed summary, AAV2-ADP attractive treatment.
sci-hub.se 参考文章(29)
Lijie Yuan, Liqiu Zhang, Xingli Dong, Hengyu Zhao, Shuyan Li, Dong Han, Xinghan Liu, Apoptin selectively induces the apoptosis of tumor cells by suppressing the transcription of HSP70 Tumor Biology. ,vol. 34, pp. 577- 585 ,(2013) , 10.1007/S13277-012-0585-Y
Rakesh K. Jain, Emmanuelle di Tomaso, Dan G. Duda, Jay S. Loeffler, A. Gregory Sorensen, Tracy T. Batchelor, Angiogenesis in brain tumours Nature Reviews Neuroscience. ,vol. 8, pp. 610- 622 ,(2007) , 10.1038/NRN2175
Faramarz- Allahdini, Abbass Amirjamshidi, Mohammad Reza-Zarei, Morteza Abdollahi, Evaluating the prognostic factors effective on the outcome of patients with glioblastoma multiformis: does maximal resection of the tumor lengthen the median survival? World Neurosurgery. ,vol. 73, pp. 128- 134 ,(2010) , 10.1016/J.WNEU.2009.06.001
Fred G. Barker, Susan M. Chang, Philip H. Gutin, Mary K. Malec, Michael W. McDermott, Michael D. Prados, Charles B. Wilson, Survival and Functional Status after Resection of Recurrent Glioblastoma Multiforme Neurosurgery. ,vol. 42, pp. 709- 719 ,(1998) , 10.1097/00006123-199804000-00013
Francesca Simonelli, Albert M Maguire, Francesco Testa, Eric A Pierce, Federico Mingozzi, Jeannette L Bennicelli, Settimio Rossi, Kathleen Marshall, Sandro Banfi, Enrico M Surace, Junwei Sun, T Michael Redmond, Xiaosong Zhu, Kenneth S Shindler, Gui-Shuang Ying, Carmela Ziviello, Carmela Acerra, J Fraser Wright, Jennifer Wellman McDonnell, Katherine A High, Jean Bennett, Alberto Auricchio, Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Molecular Therapy. ,vol. 18, pp. 643- 650 ,(2010) , 10.1038/MT.2009.277
Lijie Yuan, Hengyu Zhao, Liqiu Zhang, Xinghan Liu, The efficacy of combination therapy using adeno-associated virus-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma Tumor Biology. ,vol. 34, pp. 3027- 3034 ,(2013) , 10.1007/S13277-013-0867-Z
Francesco Testa, Albert M. Maguire, Settimio Rossi, Eric A. Pierce, Paolo Melillo, Kathleen Marshall, Sandro Banfi, Enrico M. Surace, Junwei Sun, Carmela Acerra, J. Fraser Wright, Jennifer Wellman, Katherine A. High, Alberto Auricchio, Jean Bennett, Francesca Simonelli, Three-Year Follow-up after Unilateral Subretinal Delivery of Adeno-Associated Virus in Patients with Leber Congenital Amaurosis Type 2 Ophthalmology. ,vol. 120, pp. 1283- 1291 ,(2013) , 10.1016/J.OPHTHA.2012.11.048
Petra Knizetova, Jiri Ehrmann, Alice Hlobilkova, Iveta Vancova, Ondrej Kalita, Zdenek Kolar, Jiri Bartek, Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay. Cell Cycle. ,vol. 7, pp. 2553- 2561 ,(2008) , 10.4161/CC.7.16.6442
Rong Wang, Kalyani Chadalavada, Jennifer Wilshire, Urszula Kowalik, Koos E. Hovinga, Adam Geber, Boris Fligelman, Margaret Leversha, Cameron Brennan, Viviane Tabar, Glioblastoma stem-like cells give rise to tumour endothelium Nature. ,vol. 468, pp. 829- 833 ,(2010) , 10.1038/NATURE09624
A. Sottoriva, I. Spiteri, S. G. M. Piccirillo, A. Touloumis, V. P. Collins, J. C. Marioni, C. Curtis, C. Watts, S. Tavare, Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 4009- 4014 ,(2013) , 10.1073/PNAS.1219747110