Levels of Organochlorine Pesticides Are Associated with Amyloid Aggregation in Apex Avian Brains.
作者： Kelly A. Heys , Richard F. Shore , M. Glória Pereira , Francis L. Martin
关键词:
摘要: Organochlorine (OC) pesticides pose a significant environmental risk to wildlife and humans have been associated with Alzheimer’s disease (AD). This study aims spectroscopically analyze brains from free-flying birds link the results OC exposure consequent amyloid aggregation. As long-lived apex predators, predatory represent sentinel species similar humans. Therefore, implications for both may also add our understanding of role play in development AD. Brains wild Sparrowhawks were analyzed using ATR-FTIR Raman spectroscopy Congo red staining; correlated pesticide concentrations livers. Effects sex- age-dependent alterations seen lipids protein secondary structure. A shift α-helix β-sheet conformation proteins indicated that >7.18 μg/g lead cerebral
acs.org
uclan.ac.uk
core.ac.uk
harvard.edu
sci-hub.se 参考文章(43)
Snježana Herceg Romanić, Darija Klinčić, Zorana Kljaković-Gašpić, Josip Kusak, Slaven Reljić, Đuro Huber, Organochlorine pesticides and polychlorinated biphenyl congeners in wild terrestrial mammals from Croatia: Interspecies comparison of residue levels and compositions. Chemosphere. ,vol. 137, pp. 52- 58 ,(2015) , 10.1016/J.CHEMOSPHERE.2015.05.026
Thuy Lam Thuy Lam, PL Williams, MM Lee, SA Korrick, LS Birnbaum, JS Burns, O Sergeyev, B Revich, LM Altshul, DG, Jr Patterson, R Hauser, Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys Environmental Health Perspectives. ,vol. 123, pp. 1216- 1221 ,(2015) , 10.1289/EHP.1409022
Nicola S. Clayton, Nathan J. Emery, Avian Models for Human Cognitive Neuroscience: A Proposal Neuron. ,vol. 86, pp. 1330- 1342 ,(2015) , 10.1016/J.NEURON.2015.04.024
Marc A. Cadieux, Derek C. G. Muir, Pierre Béland, Brendan E. Hickie, Lactational Transfer of Polychlorinated-Biphenyls (PCBs) and Other Organochlorines in St. Lawrence Beluga Whales (Delphinapterus leucas). Archives of Environmental Contamination and Toxicology. ,vol. 70, pp. 169- 179 ,(2016) , 10.1007/S00244-015-0223-Y
Cedrique Temoka, Jingxian Wang, Yonghong Bi, Dominik Deyerling, Gerd Pfister, Bernhard Henkelmann, Karl-Werner Schramm, Concentrations and mass fluxes estimation of organochlorine pesticides in Three Gorges Reservoir with virtual organisms using in situ PRC-based sampling rate. Chemosphere. ,vol. 144, pp. 1521- 1529 ,(2016) , 10.1016/J.CHEMOSPHERE.2015.10.007
Michele Arienzo, Stefano Albanese, Annamaria Lima, Claudia Cannatelli, Francesco Aliberti, Flavia Cicotti, Shiuhua Qi, Benedetto De Vivo, Assessment of the concentrations of polycyclic aromatic hydrocarbons and organochlorine pesticides in soils from the Sarno River basin, Italy, and ecotoxicological survey by Daphnia magna. Environmental Monitoring and Assessment. ,vol. 187, pp. 52- ,(2015) , 10.1007/S10661-015-4272-5
Andrias O. O'Reilly, Bhupinder P. S. Khambay, Martin S. Williamson, Linda M. Field, B. A. WAllace, T. G. Emyr Davies, Modelling insecticide-binding sites in the voltage-gated sodium channel. Biochemical Journal. ,vol. 396, pp. 255- 263 ,(2006) , 10.1042/BJ20051925
I. Newton, I. Wyllie, A. Asher, Long-term trends in organochlorine and mercury residues in some predatory birds in Britain. Environmental Pollution. ,vol. 79, pp. 143- 151 ,(1993) , 10.1016/0269-7491(93)90064-U
Ioannis Zaganas, Stefania Kapetanaki, Vassileios Mastorodemos, Konstantinos Kanavouras, Claudio Colosio, Martin F. Wilks, Aristidis M. Tsatsakis, Linking pesticide exposure and dementia: what is the evidence? Toxicology. ,vol. 307, pp. 3- 11 ,(2013) , 10.1016/J.TOX.2013.02.002
Zanyar Movasaghi, Shazza Rehman, Dr. Ihtesham ur Rehman, Fourier Transform Infrared (FTIR) Spectroscopy of Biological Tissues Applied Spectroscopy Reviews. ,vol. 43, pp. 134- 179 ,(2008) , 10.1080/05704920701829043