Vascular and interstitial barriers to delivery of therapeutic agents in tumors.

作者: Rakesh K. Jain

DOI: 10.1007/BF00046364

关键词:

摘要: … cells alone has failed to explain the nonuniform uptake of … Note that elevated pressure in the central region retards the … with large tumor dose deposition and large depths of penetration; …

参考文章(53)
G A Kirk, J M Slater, D S Gridley, D R Stickney, Enhancement of monoclonal antibody binding to melanoma with single dose radiation or hyperthermia. NCI monographs : a publication of the National Cancer Institute. ,vol. 3, pp. 47- 52 ,(1987)
A. M. Dvorak, J. A. Nagy, H. F. Dvorak, J. T. Dvorak, Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. American Journal of Pathology. ,vol. 133, pp. 95- 109 ,(1988)
Giovanni Astarita, Mass transfer with chemical reaction ,(1967)
Rakesh K. Jain, Jonas M. Weissbrod, James Wel, Mass transport in tumors: characterization and applications to chemotherapy. Advances in Cancer Research. ,vol. 33, pp. 251- 310 ,(1980) , 10.1016/S0065-230X(08)60672-7
Flora H. Grantham, Thomas P. Butler, Pietro M. Gullino, Bulk Transfer of Fluid in the Interstitial Compartment of Mammary Tumors Cancer Research. ,vol. 35, pp. 3084- 3088 ,(1975)
Rakesh K. Jain, Eva Marie Sevick, Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure. Cancer Research. ,vol. 49, pp. 3506- 3512 ,(1989)
Laurence T. Baxter, Rakesh K. Jain, Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvascular Research. ,vol. 41, pp. 5- 23 ,(1991) , 10.1016/0026-2862(91)90003-T
James Wei, Pietro M. Gullino, Edward A. Swabb, Diffusion and Convection in Normal and Neoplastic Tissues Cancer Research. ,vol. 34, pp. 2814- 2822 ,(1974)
Flora H. Grantham, Pietro M. Gullino, THE VASCULAR SPACE OF GROWING TUMORS. Cancer Research. ,vol. 24, pp. 1727- 1732 ,(1964)
Rakesh K. Jain, Michelle A. Clauss, Interstitial Transport of Rabbit and Sheep Antibodies in Normal and Neoplastic Tissues Cancer Research. ,vol. 50, pp. 3487- 3492 ,(1990)