COMPARATIVE ANALYSIS OF EXPRESSION OF ANGIOGENIC FACTORS AND CD44 GENE IN HUMAN GLIOMA AND NEUROBLASTOMA CELL LINES IN VITRO
作者： Dragana Jankovic , Ana Stojkovic , Milica Pesic , Selma Kanazir , Ljubisav Rakic
DOI: 10.2298/JMH0401019J
关键词:
摘要: Summary: Angiogenesis is essential for tumor growth and relies on the production of angiogenic factors. By comparative analysis using RT-PCR method factors: VEGF, bFGF, PDGF-A, angiogenin1 IL-8 we established level expression these genes necessary angiogenesis in glioma neuroblastoma cell lines. Our analyses were also extended to CD44 gene, which plays an important role cascade metastasis progression brain tumors. Significant differences gene factors between two lines observed throughout this study can be used as a prognostic marker predicting clinical outcome human tumors at time initial staging.
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