Hepatic Glucose Production and Splanchnic Glucose Exchange in Hyperthyroidism

摘要: Hepatic glucose production (HGP) and net splanchnic balance (NSGB) were simultaneously determined in the basal state 8 hyperthyroid patients 10 normal subjects using iv infusion of [3H]3-glucose hepatic venous catheter technique. Splanchnic uptake (SGU) was calculated as difference between HGP NSGB. SGU also measured by determining extraction ratio across bed. In 5 a renal vein catheterized state. The influence increased endogenous insulin secretion [stimulated low rate (2 mg/kg . min)] on exchange examined. Basal (measured with [3H]3-glucose) 20% [14.2 +/- 0.6 (SEM) mumol/kg min] compared to (11.9 0.6, P less than 0.02). marked contrast, NSGB output slightly but not significantly decreased group. patients, both techniques, more 2-fold higher group (P 0.02-P 0.005). gluconeogenic precursors (lactate, pyruvate, glycerol) 20-120% patient During glucose, plasma levels (66% vs. 37%, 0.05). Nevertheless, markedly suppressed 0.01), whereas augmented reverted normal. unchanged groups. No could be demonstrated either We conclude that hyperthyroidism, occurs face an or reduced delivery extrasplanchnic tissue. This discrepancy can ascribed glucose. These findings raise possibility futile cycling liver mechanism oxygen consumption hyperthyroidism. data demonstrate diminished inhibitory effect production, suggesting presence resistance