SU6668 inhibits Flk-1/KDR and PDGFRβ in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice
作者： A. Douglas Laird , James G. Christensen , Guangmin Li , Jeremy Carver , Kimberly Smith
关键词:
摘要: … Potent, dose-dependent inhibition of Flk-1/KDR activity in vivo … associated with rapid vessel killing in tumors, leading to broad … tumor MVD and proliferation were dose dependent in A431 …
fasebj.org参考文章(23)
Julie M. Cherrington, Laurie M. Strawn, Laura K. Shawver, New paradigms for the treatment of cancer: The role of anti-angiogenesis agents Advances in Cancer Research. ,vol. 79, pp. 1- 38 ,(2000) , 10.1016/S0065-230X(00)79001-4
David J. McConkey, Corazon D. Bucana, Wenbiao Liu, Michael R. Wilson, Darren W. Davis, Raymond M. Shaheen, Lee M. Ellis, Brian K. Zebrowski, Gerald McMahon, Antiangiogenic Therapy Targeting the Tyrosine Kinase Receptor for Vascular Endothelial Growth Factor Receptor Inhibits the Growth of Colon Cancer Liver Metastasis and Induces Tumor and Endothelial Cell Apoptosis Cancer Research. ,vol. 59, pp. 5412- 5416 ,(1999)
Amy R. Nelson, Barbara Fingleton, Mace L. Rothenberg, Lynn M. Matrisian, Matrix Metalloproteinases: Biologic Activity and Clinical Implications Journal of Clinical Oncology. ,vol. 18, pp. 1135- 1135 ,(2000) , 10.1200/JCO.2000.18.5.1135
Peter Klint, Lena Claesson-Welsh, Signal transduction by fibroblast growth factor receptors. Frontiers in Bioscience. ,vol. 4, pp. 165- ,(1999) , 10.2741/KLINT
Per Lindahl, Bengt R Johansson, Per Leveen, Christer Betsholtz, Pericyte loss and microaneurysm formation in PDGF-B-deficient mice Science. ,vol. 277, pp. 242- 245 ,(1997) , 10.1126/SCIENCE.277.5323.242
Hans-Peter Gerber, Amy McMurtrey, Joe Kowalski, Minhong Yan, Bruce A. Keyt, Vishva Dixit, Napoleone Ferrara, Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway Journal of Biological Chemistry. ,vol. 273, pp. 30336- 30343 ,(1998) , 10.1074/JBC.273.46.30336
Napoleone Ferrara, None, VEGF: an update on biological and therapeutic aspects. Current Opinion in Biotechnology. ,vol. 11, pp. 617- 624 ,(2000) , 10.1016/S0958-1669(00)00153-1
Douglas Hanahan, Judah Folkman, Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis Cell. ,vol. 86, pp. 353- 364 ,(1996) , 10.1016/S0092-8674(00)80108-7
Laura E. Benjamin, Dragan Golijanin, Ahuva Itin, Dov Pode, Eli Keshet, Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal Journal of Clinical Investigation. ,vol. 103, pp. 159- 165 ,(1999) , 10.1172/JCI5028
B. Liu, H.M. Earl, D. Baban, M. Shoaibi, A. Fabra, D.J. Kerr, L.W. Seymour, Melanoma Cell Lines Express VEGF Receptor KDR and Respond to Exogenously Added VEGF Biochemical and Biophysical Research Communications. ,vol. 217, pp. 721- 727 ,(1995) , 10.1006/BBRC.1995.2832