Passive Antibody-Mediated Immunotherapy for the Treatment of Malignant Gliomas

摘要: Despite advances in understanding the molecular mechanisms of brain cancer, outcome patients with malignant gliomas treated according to current standard care remains poor. Novel therapies are needed, and immunotherapy has emerged great promise. The diffuse infiltration is a major challenge effective treatment; advantage accessing entire specificity for tumor cells. Therapeutic immune approaches include cytokine therapy, passive immunotherapy, active immunotherapy. Cytokine therapy involves administration immunomodulatory cytokines activate system. Active generation or augmentation an response, typically by vaccination against antigens. Passive connotes either adoptive which tumor-specific cells expanded ex vivo reintroduced into patient, antibody-mediated therapy. In this article, authors discuss preclinical clinical studies that have used otherwise known as serotherapy, treatment gliomas.