摘要: In 1997, the PTEN gene (phosphatase and tensin homolog deleted on chromosome 10) was identified as a tumor suppressor long arm of 10. Since then, important progress has been made with respect to understanding role Pten protein in normal development brain well molecular pathogenesis human gliomas. This review summarizes current state art concerning involvement aberrant function different biologic features malignant gliomas, such loss cell-cycle control uncontrolled cell proliferation, escape from apoptosis, invasion, neoangiogenesis. Most tumor-suppressive properties are dependent its lipid phosphatase activity, which inhibits phosphatidylinositol-3'-kinase (PI3K)/Akt signaling pathway through dephosphorylation phosphatidylinositol-(3,4,5)-triphosphate. The additional dual-specificity may also play glioma pathogenesis. Besides wealth data elucidating functional roles Pten, recent studies suggest diagnostic significance alterations marker for poor prognosis anaplastic astrocytomas oligodendrogliomas. Furthermore, possibility selective targeting mutant cells by specific pharmacologic inhibitors members Pten/PI3K/Akt opens up new perspectives targeted therapy
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