Effects of lidocaine-HCl salt and benzocaine on the expansion of lipid monolayers employed as bio-mimicking cell membrane.

摘要: Abstract Effects of lidocaine–HCl salt and benzocaine on the expansion lipid monolayers employed as bio-mimicking cell membrane were investigated using Langmuir–Blodgett film balance to figure out molecular mechanism for anesthesia by these local anesthetics. Lidocaine–HCl in subphase expanded monolayer phosphatidyl choline (PC) ethanolamine (PE). Benzocaine was not mixed with lipids monolayer, but surface water saturated same case salt. Even though this study can explain whole benzocaine, it be asserted from results that contribute, at least partially, generation anesthesia.