Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
作者： RC Fitzgerald , C Caldas
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摘要: Approximately 1–3% of gastric cancers arise as a result inherited cancer predisposition syndromes. These may be the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% families with autosomal dominant to type cancers. This subset been termed hereditary (HDGC).
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