A Recurrent 19q11–12 Breakpoint Suggested by Cytogenetic and Fluorescence In Situ Hybridization Analysis of Three Glioblastoma Cell Lines
作者： Ivana Magnani , Elena Chiariello , Anna Maria Fuhrman Conti , Gaetano Finocchiaro
DOI: 10.1016/S0165-4608(98)00190-3
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摘要: Abstract Loss of genetic material at chromosome 19 is a rather frequent finding in malignant gliomas. heterozygosity region 19q13.3 common oligodendrogliomas and also present, together with other alterations on the same chomosome, glioblastoma multiforme (GBM). Here we describe results cytogenetic fluorescence situ hybridization analysis three GBM cell lines which series complex chromosomal rearrangements affecting were present. These suggest presence breakpoint 19q11–12 may point to localization fragile site and/or tumor suppressor gene(s) pericentromeric 19.
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