Dietary Protein, Enhancement of N-Nitrosomethylurea-induced Mammary Carcinogenesis, and Their Effect on Hormone Regulation in Rats
作者： E. J. Hawrylewicz , Juei Ming Liu , Henry H. Huang
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摘要: The effect of supplemental dietary protein (casein) fed with high fat diets was investigated using the N -nitrosomethylurea-induced mammary tumor model. Isocaloric containing casein and corn oil at 19 15% (normal protein-high fat) or 33 (high were ad libitum to Sprague-Dawley mother rats. Female offspring continued on diet. Food consumption growth curves similar over entire period. -Nitrosomethylurea (50 mg/kg body weight) saline administered 7 8 weeks age via tail vein. Dietary had no serum prolactin hormone throughout estrous cycle: Prior carcinogen administration, old, proestrus 5 p.m., 231.6 ± 141.0 (SE) ng/ml (12 rats) versus 292.2 (13 for normal diet groups, respectively. No difference noted after injection 9, 13, 28, age. Similarly activity. Tumor latency incidence 100% in (24 (39 groups 28 treatment. number tumors per rat (4.38 0.37 2.87 0.35, P < 0.002) average weight (17.97 2.63 9.94 2.92 g) significantly greater group. Study indicates that treatment did not alter regulation during cycle. However, increased enhancing burden.
aacrjournals.org参考文章(15)
J H Weisburger, Y Maeura, D O Thompson, L A Cohen, Influence of dietary medium-chain triglycerides on the development of N-methylnitrosourea-induced rat mammary tumors. Cancer Research. ,vol. 44, pp. 5023- 5028 ,(1984)
Margaret Goodrich-Smith, Jane Chiusano, Clifford W. Welsch, Richard C. Moon, Carolyn K. Brown, Synergistic effect of chronic prolactin suppression and retinoid treatment in the prophylaxis of N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats. Cancer Research. ,vol. 40, pp. 3095- 3098 ,(1980)
Amor El Abed, Bernard Kerdelhue, Inhibition of preovulatory gonadotropin secretion and stimulation of prolactin secretion by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats. Cancer Research. ,vol. 39, pp. 4700- 4705 ,(1979)
Brian Pruitt, David P. Rose, Erdoḡan Ertürk, Patricia Stauber, George T. Bryan, Influence of Dosage Schedule on the Biological Characteristics of N-Nitrosomethylurea-induced Rat Mammary Tumors Cancer Research. ,vol. 40, pp. 235- 239 ,(1980)
Steven K. Clinton, C. Richard Truex, Willard J. Visek, Dietary Protein, Aryl Hydrocarbon Hydroxylase and Chemical Carcinogenesis in Rats The Journal of Nutrition. ,vol. 109, pp. 55- 62 ,(1979) , 10.1093/JN/109.1.55
Warren C. Stern, Maravene Miller, William B. Forbes, Peter J. Morgane, Oscar Resnick, Ontogeny of the levels of biogenic amines in various parts of the brain and in peripheral tissues in normal and protein malnourished rats Experimental Neurology. ,vol. 49, pp. 314- 326 ,(1975) , 10.1016/0014-4886(75)90214-9
G Hems, The contributions of diet and childbearing to breast-cancer rates. British Journal of Cancer. ,vol. 37, pp. 974- 982 ,(1978) , 10.1038/BJC.1978.142
J.W. Simpkins, P.S. Kalra, S.P. Kalra, Effects of Testosterone on Catecholamine Turnover and LHRH Contents in the Basal Hypothalamus and Preoptic Area Neuroendocrinology. ,vol. 30, pp. 94- 100 ,(1980) , 10.1159/000122982
Morris H. Ross, Edward D. Lustbader, Gerrit Bras, Dietary practices of early life and spontaneous tumors of the Rat Nutrition and Cancer. ,vol. 3, pp. 150- 167 ,(1981) , 10.1080/01635588109513717
David P. Rose, John J. Noonan, Influence of Prolactin and Growth Hormone on Rat Mammary Tumors Induced by N-Nitrosomethylurea Cancer Research. ,vol. 42, pp. 35- 38 ,(1982)