Gastric cancer and gene copy number variation: emerging cancer drivers for targeted therapy.

摘要: Gastric cancer (GC) is among the most common malignancy in world with poor prognosis and limited treatment options. It has been established that gastric carcinogenesis caused by a complex interaction between host environmental factors. Copy number variation (CNV) refers to form of genomic structural results abnormal gene copy numbers, including amplification, gain, loss deletion. DNA CNV an important influential factor for expression both protein-coding non-coding genes, affecting activity various signaling pathways. arises as result preferential selection favors development, thus, targeting amplified 'driver genes' GC may provide novel opportunities personalized therapy. The detection CNVs chromosomal or mitochondrial from tissue blood samples assist diagnosis, targeted therapy GC. In this review, we discuss recent discoveries shed light on molecular pathogenesis GC, specific emphasis display diagnostic, prognostic therapeutic significances