Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy.

作者: Qiushi Wang , Yong He , Xin Yang , Yubo Wang , Hualiang Xiao

DOI: 10.1186/1471-2466-14-83

关键词:

摘要: Background The discovery of the fusion gene echinodermmicro tubule associated proteinlike 4-anaplastic lymphoma kinase, EML4-ALK, in patients with non-small-cell lung cancer has led to remarkable development anaplastic kinase inhibitors, such as crizotinib. Consequently, clinical outcomes these have improved dramatically. Herein, we report case a woman ALK translocation-squamous cell who experienced tumor response crizotinib after two courses failed chemotherapy.

参考文章(9)
Daisy Wing-Sze Wong, Elaine Lai-Han Leung, Kimpton Kam-Ting So, Issan Yee-San Tam, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, Kwok-Keung Ho, Joseph Siu-Kie Au, Lap-Ping Chung, Maria Pik Wong, , The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. ,vol. 115, pp. 1723- 1733 ,(2009) , 10.1002/CNCR.24181
Kentaro Inamura, Kengo Takeuchi, Yuki Togashi, Kimie Nomura, Hironori Ninomiya, Michiyo Okui, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Manabu Soda, Young Lim Choi, Toshiro Niki, Hiroyuki Mano, Yuichi Ishikawa, EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers Journal of Thoracic Oncology. ,vol. 3, pp. 13- 17 ,(2008) , 10.1097/JTO.0B013E31815E8B60
Gouji Toyokawa, Mitsuhiro Takenoyama, Sawori Watanabe, Ryo Toyozawa, Eiko Inamasu, Miyako Kojo, Yoshimasa Shiraishi, Yosuke Morodomi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Kenichi Taguchi, Takashi Seto, Yukito Ichinose, Dramatic response to crizotinib in an ALK-positive adenocarcinoma patient with disseminated intravascular coagulation. Journal of Thoracic Oncology. ,vol. 8, ,(2013) , 10.1097/JTO.0B013E3182A008ED
Su-Jung Kim, Dong-Wan Kim, Tae Min Kim, Se-Hoon Lee, Dae Seog Heo, Yung-Jue Bang, None, Remarkable Tumor Response to Crizotinib in a 14-Year-Old Girl With ALK-Positive Non–Small-Cell Lung Cancer Journal of Clinical Oncology. ,vol. 30, ,(2012) , 10.1200/JCO.2011.39.9766
Alice T. Shaw, Beow Y. Yeap, Mari Mino-Kenudson, Subba R. Digumarthy, Daniel B. Costa, Rebecca S. Heist, Benjamin Solomon, Hannah Stubbs, Sonal Admane, Ultan McDermott, Jeffrey Settleman, Susumu Kobayashi, Eugene J. Mark, Scott J. Rodig, Lucian R. Chirieac, Eunice L. Kwak, Thomas J. Lynch, A. John Iafrate, Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK Journal of Clinical Oncology. ,vol. 27, pp. 4247- 4253 ,(2009) , 10.1200/JCO.2009.22.6993
Sandjar Djalalov, Jaclyn Beca, Jeffrey S. Hoch, Murray Krahn, Ming-Sound Tsao, Jean-Claude Cutz, Natasha B. Leighl, Cost Effectiveness of EML4-ALK Fusion Testing and First-Line Crizotinib Treatment for Patients With Advanced ALK-Positive Non–Small-Cell Lung Cancer Journal of Clinical Oncology. ,vol. 32, pp. 1012- 1019 ,(2014) , 10.1200/JCO.2013.53.1186
Richard Schwab, Istvan Petak, Mihaly Kollar, Ferenc Pinter, Edit Varkondi, Andrea Kohanka, Helga Barti-Juhasz, Julia Schönleber, Diana Brauswetter, Laszlo Kopper, Laszlo Urban, Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement. Lung Cancer. ,vol. 83, pp. 109- 111 ,(2014) , 10.1016/J.LUNGCAN.2013.10.006
Scott J Rodig, Mari Mino-Kenudson, Sanja Dacic, Beow Y Yeap, Alice Shaw, Justine A Barletta, Hannah Stubbs, Kenny Law, Neal Lindeman, Eugene Mark, Pasi A Janne, Thomas Lynch, Bruce E Johnson, A John Iafrate, Lucian R Chirieac, None, Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clinical Cancer Research. ,vol. 15, pp. 5216- 5223 ,(2009) , 10.1158/1078-0432.CCR-09-0802
Beow Y Yeap, Benjamin J Solomon, Gregory J Riely, Justin Gainor, Jeffrey A Engelman, Geoffrey I Shapiro, Daniel B Costa, Sai-Hong I Ou, Mohit Butaney, Ravi Salgia, Robert G Maki, Marileila Varella-Garcia, Robert C Doebele, Yung-Jue Bang, Kimary Kulig, Paulina Selaru, Yiyun Tang, Keith D Wilner, Eunice L Kwak, Jeffrey W Clark, A John Iafrate, D Ross Camidge, Alice T Shaw, Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncology. ,vol. 12, pp. 1004- 1012 ,(2011) , 10.1016/S1470-2045(11)70232-7