Intra-individual Change Over Time in DNA Methylation With Familial Clustering

摘要: Context Changes over time in epigenetic marks, which are modifications of DNA such as by methylation, may help explain the late onset common human diseases. However, changes methylation or other marks a given individual have not yet been investigated. Objectives To determine whether there longitudinal global individuals and to evaluate maintenance demonstrates familial clustering. Design, Setting, Participants We measured luminometric assay, quantitative measurement genome-wide on sampled at 2 visits average 11 years apart 111 from an Icelandic cohort (1991 2002-2005) 16 126 Utah sample (1982-1985 1997-2005). Main Outcome Measure Global time. Results Twenty-nine percent showed greater than 10% change (P  Conclusion These data indicate that suggest be under genetic control.