Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice

摘要: Interleukin-6 (IL-6) is known to be involved in the pathogenesis of various inflammatory diseases, but its role bleomycin (BLM)-induced lung injury and subsequent fibrotic changes remains determined. We evaluated IL-6 induced by BLM using wild-type (WT) IL-6–deficient (IL-6−/−) mice. The mice were treated intratracheally with 1 mg/kg killed 2, 7, or 21 days later. Lung Inflammation acute phase (Days 2 7) was assessed differential cell counts bronchoalveolar lavage (BAL) fluid cytokine levels lung. on Day histopathology collagen assay. On administration significant increases numbers total cells, macrophages, neutrophils BAL fluid, which attenuated IL-6−/− (P < 0.05). pathology also showed accumulation, compared WT In mice, elevated T...