In Vivo Early Corneal Biomechanical Changes After Corneal Cross-linking in Patients With Progressive Keratoconus.

摘要: PURPOSE To report early corneal biomechanical changes after cross-linking (CXL) in patients with keratoconus. METHODS Thirty-four eyes of 34 undergoing CXL for progressive keratoconus were included this prospective clinical study. Dynamic response (DCR) parameters obtained the Corvis ST (OCULUS Optikgerate GmbH; Wetzlar, Germany) assessed at baseline (day CXL) and 1 month follow-up; conversely, tomography Pentacam GmbH) was 1, 3, 6 months CXL. RESULTS At last follow-up visit (123.7 ± 69.6 days), all morphological including steepest point (Kmax) thinnest thickness (ThCT) indicated stabilization (P > .05). Comparative analyses showed a rise stiffness demonstrated by significant increase Stiffness Parameter A1 (SP-A1) Highest Concavity (SP-HC) decrease Inverse Concave Radius (1/R) Deformation Amplitude Ratio (DA Ratio) < There correlation between preoperative characteristics (Kmax, Belin/Ambrosio final D value [BAD-D], ThCT) DCR Kmax BAD-D positive DA Ratio, Deflection (DefA), 1/R negative SPA1 SP-HC. ThCT SP-A1 SP-HC DefA, 1/R. CONCLUSIONS This study suggests that new are able to detect biomechanics following those measurable before shape modifications take place. Based on these results, authors suggest use metrics assess efficacy cross-linking. [J Refract Surg. 2017;33(12):840-846.].