Adult stem cells and uses thereof

作者: Jin-Lian Tsai , Kung-Kai Kuo , Tsai-Ming Lin , Chia-Cheng Chang

DOI:

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摘要: Disclosed are compositions and methods for isolating, immortalizing differentiating adult stem cells, example, particular human clonal liver cells or adipose including specialized cell culture media the isolation propagation of such cells. Also disclosed screening toxicity, carcinogenicity therapeutic activity using immortalized differentiated derivatives thereof. In addition, treatment their thereof disclosed.

参考文章(15)
Malcolm Alison, Liver stem cells: a two compartment system Current Opinion in Cell Biology. ,vol. 10, pp. 710- 715 ,(1998) , 10.1016/S0955-0674(98)80111-7
Keisuke Nishioka, Yoshihiro Fujimori, Tomoko Hashimoto-Tamaoki, Shunro Kai, Huiying Qiu, Naoya Kobayashi, Noriaki Tanaka, Karen Westerman, Philippe Leboulch, Hiroshi Hara, Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells. International Journal of Oncology. ,vol. 23, pp. 925- 932 ,(2003) , 10.3892/IJO.23.4.925
Herbert D. Soule, Robert J. Pauley, Terry J. Paine, Immortal human mammary epithelial cell sublines ,(1991)
James E. Trosko, Chia-Cheng Chang, Melinda R. Wilson, Brad Upham, Tomonori Hayashi, Margaret Wade, Gap junctions and the regulation of cellular functions of stem cells during development and differentiation. Methods. ,vol. 20, pp. 245- 264 ,(2000) , 10.1006/METH.1999.0941
Tsai-Ming Lin, Jin-Lian Tsai, Sin-Daw Lin, Chung-Sheng Lai, Chia-Cheng Chang, Accelerated growth and prolonged lifespan of adipose tissue-derived human mesenchymal stem cells in a medium using reduced calcium and antioxidants. Stem Cells and Development. ,vol. 14, pp. 92- 102 ,(2005) , 10.1089/SCD.2005.14.92
J. Smith, E. Ladi, M. Mayer-Proschel, M. Noble, Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 10032- 10037 ,(2000) , 10.1073/PNAS.170209797
J. Goolsby, M. C. Marty, D. Heletz, J. Chiappelli, G. Tashko, D. Yarnell, P. S. Fishman, S. Dhib-Jalbut, C. T. Bever, B. Pessac, D. Trisler, Hematopoietic progenitors express neural genes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 14926- 14931 ,(2003) , 10.1073/PNAS.2434383100
Gianluca D'Ippolito, Sylma Diabira, Guy A Howard, Philippe Menei, Bernard A Roos, Paul C Schiller, Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. Journal of Cell Science. ,vol. 117, pp. 2971- 2981 ,(2004) , 10.1242/JCS.01103
Hiroshi Mizuno, Hiko Hyakusoku, Mesengenic potential and future clinical perspective of human processed lipoaspirate cells. Journal of Nippon Medical School. ,vol. 70, pp. 300- 306 ,(2003) , 10.1272/JNMS.70.300