Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas

摘要: Loss of heterozygosity (LOH) for chromosome 10 is the most frequent genetic abnormality observed in high-grade gliomas. We have used fluorescent microsatellite markers to examine a series 83 patients, 34 with anaplastic astrocytoma (grade 3) and 49 glioblastoma multiforme 4), LOH 10. Genotype analysis revealed all informative 12 (35%) patients grade 3 29 (59%) 4 tumours respectively, while partial was found further eight (24%) ten (20%) tumours. Partial LOH, confined long arm (10q) six short (10p) three cases, alleles from both arms were lost four cases. Five (one 4) showed heterogeneity respect loss at different loci. There correlation between any poorer performance status presentation (chi2 P = 0.005) increasing age diagnosis (Mann-Whitney U-test 0.034) but not tumour p= 0.051). A Cox multivariate model survival duration identified (proportional hazards (PH), P= 0.004), (PH, 0.012) 0.009) as only independent prognostic variables. Specifically, able identify subgroup who had significantly shorter time. conclude that an independent, adverse variable glioma.