miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer

摘要: MicroRNA (miR)-217 has been reported to participate in carcinogenesis and tumor progression several cancers; however, its expression biological functions colorectal cancer (CRC) are still unclear. The present study demonstrated that miR-217 was significantly higher matched adjacent noncancerous tissues than CRC (P<0.001). In addition, it observed low-grade exhibited greater of compared with high-grade (P<0.05). Kaplan-Meier survival Cox regression analyses revealed overall rates were poorer the low-expression group relative high-expression (P<0.005). Next, a potential target, mitogen-activated protein kinase (MAPK) 1, identified. Upregulation could downregulate MAPK1 expression. cells overexpressing cell growth inhibition by significant enhancement apoptosis vitro. further investigated MAPK signaling pathway verify mechanisms, KRAS Raf-1 downregulated miR-217-overexpressing RKO cells. Taken together, our results inhibits enhances CRC, this is associated downregulation signaling. These indicate promising therapeutic target for treatment CRC.