Early Infant Diet and Islet Autoimmunity in the TEDDY Study

摘要: OBJECTIVE To examine duration of breastfeeding and timing complementary foods risk islet autoimmunity (IA). RESEARCH DESIGN AND METHODS The Environmental Determinants Diabetes in the Young (TEDDY) study prospectively follows 8,676 children with increased genetic type 1 diabetes (T1D) U.S., Finland, Germany, Sweden. This included 7,563 at least 9 months follow-up. Blood samples were collected every 3 from birth to evaluate IA, defined as persistent, confirmed positive antibodies insulin (IAAs), GAD, or insulinoma antigen-2. We examined associations between diet IA using Cox regression models adjusted for country, T1D family history, HLA genotype, sex, early probiotic exposure. Additionally, we investigated martingale residuals log-rank statistics determine cut points ages dietary exposures. RESULTS Later introduction gluten was associated any IAA. hazard ratios (HRs) 1-month delay 1.05 (95% CI 1.01, 1.10; P = 0.02) 1.08 1.00, 1.16; 0.04), respectively. Martingale residual analysis suggested that age could be grouped months. introducing before 4 lower (HR 0.68; 95% 0.47, 0.99), it later than higher 1.57; 1.07, 2.31) age. CONCLUSIONS gluten-containing cereals should studied further.