Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 ( MDM2 ) gene
作者： Kirstin Mittelstrass , Wiebke Sauter , Albert Rosenberger , Thomas Illig , Maria Timofeeva
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摘要: The polymorphism SNP309 (rs2279744) in the promoter region of MDM2 gene has been shown to alter protein expression and may play a role susceptibility lung cancer. is key inhibitor p53 several mechanisms MDM2/p53 interactions are presently known: modulating DNA-repair, cell-cycle control, cell growth apoptosis.
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