Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy

摘要: In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) multiple system atrophy (MSA), we compared the disease course patients consecutively referred between 1987 1999 followed December 1999. Thirty-nine PSP 74 MSA were diagnosed according commonly accepted criteria. Length was ascertained from death certificates or by contacting relatives. Ten-year after onset 29% for both disorders. Median 7.0 years 7.5 (MSA). Neither age, symptoms at onset, disability diagnosis predicted survival. At diagnosis, all had oculomotor palsy, whereas 89% dysautonomia; bradykinesia falls most frequent common signs. Distinctive signs palilalia, cognitive impairment hyperreflexia in PSP; hypophonia, anterocollis dysautonomia MSA. responded better levodopa. Attention distinctive can improve differential inform subsequent management.