EGFR overexpression and radiation response in glioblastoma multiforme.

摘要: Abstract Purpose: Recent studies have suggested relative radioresistance in glioblastoma multiforme (GM) tumors older patients, consistent with their shorter survival. Two common molecular genetic abnormalities GM are age related: epidermal growth factor receptor (EGFR) overexpression patients and p53 mutations younger patients. We tested whether these correlated clinical heterogeneity response to radiation treatment. Methods Materials: Radiographically assessed (5-level scale) was EGFR immunoreactivity, exon 5–8 mutation status 170 treated using 2 prospective protocols. Spearman rank correlation proportional-odds ordinal regression were used for univariate multivariate analysis. Results: Positive immunoreactivity predicted poor radiographically (p = 0.046). Thirty-three percent of no had good responses (>50% reduction tumor size by CT or MRI), compared 18% intermediate staining 9% strong staining. There significant relationship between response. Significant relationships noted score age. Conclusion: The observed some GMs is associated EGFR.